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Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma

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  • Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma
Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma
2018 11-10

Authors: Eisemann T, Costa B, Harter PN, Wick W, Mittelbronn M, Angel P, Peterziel H

ABSTRACT

Treatment options of glioblastoma, the most aggressive primary brain tumor with frequent relapses and high mortality, are still very limited, urgently calling for novel therapeutic targets. Expression of the glycoprotein podoplanin correlates with poor prognosis in various cancer entities, including glioblastoma. Furthermore, podoplanin has been associated with tumor cell migration and proliferation in vitro; however, experimental data on its function in gliomagenesis in vivo are still missing. Hence, we have functionally investigated the impact of podoplanin on glioblastoma in a preclinical mouse model to evaluate its potential as a therapeutic target.

Neuro-Oncology, Volume 21, Issue 3, 326-336

Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma