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Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions

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Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions
2020 06-09

Authors: Baldini F, Hertel J, Sandt E, Thinnes CC, Neuberger-Castillo L, Pavelka L, Betsou F, Krüger R, Thiele I, on behalf of the NCER-PD Consortium

Abstract

Background:

Parkinson’s disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their functional consequences remain unclear. Herein, we addressed this question by an analysis of stool samples from the Luxembourg Parkinson’s Study (n = 147 typical PD cases, n = 162 controls).

BMC Biology

Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions