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Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors

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Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors
2020 02-04

Authors: Ronellenfitsch W, Harter PN, Kirchner M, Heining C, Hutter B, Gieldon L, Schittenhelm J, Schuhmann MU, Tatagiba, Marquardt G, Wagner M, Endris V, Brandts CH, Mautner VF, Schröck E, Weichert W, Brors B, von Deimling A, Mittelbronn M, Steinbach JP, E. Reuss DE, Glimm H, Stenzinger A, Fröhling S

Abstract

BACKGROUND: Neurofibroma/schwannoma hybrid nerve sheath tumors (N/S HNSTs) are neoplasms associated with larger nerves that occur sporadically and in the context of schwannomatosis or neurofibromatosis type 2 or 1. Clinical management of N/S HNSTs is challenging, especially for large tumors, and established systemic treatments are lacking.

The Journal of Clinical Investigation

Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors