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As part of its responsibilities, the LNS develops research activities in collaboration with ad hoc partners in Luxembourg and abroad and regularly produces research results in its fields of competence with internationally recognized excellence.
Research at the LNS is based on competent teams working with public authorities, the Luxembourg National Research Fund (FNR), public research centers and the University of Luxembourg as well as with international academic and research institutions.
Here you can find a selection of current research projects. Good discovery !
Goal : To build a European COVID-19 and emerging infectious diseases platform trials network with a coherent strategic mechanism to ensure the best scientific outcomes. The project includes two phases: the phase I aims at evaluating the safety and efficacy of different antiviral treatment protocols, the phase II is dedicated to measure viral loads in respiratory samples and plasma, to determine the viral excretion kinetics and evaluate the antiviral effect of the tested drugs in different countries.
Service : Department of Microbiology
LNS contact : trung.nguyen@lns.etat.lu
Duration : 5 years (2020-2025)
Partners : INSERM, LIH, Biomérieux
Financing : INSERM
Goal : Investigate clinical and genomic characteristics to identify the risk factors for severe Covid in Luxembourg pediatric population.
Service : Department of Microbiology
LNS contact : tamir.abdelrahman@lns.etat.lu
Duration : 6 months (2020-2021)
Partners : CHL, Direction de la Santé
Goal : Evaluation of an innovative approach to detect Covid in voice via an algorithm by comparison to SARS-CoV-2 RT-qPCR results.
Service : Department of Microbiology
LNS contact : guillaume.fournier@lns.etat.lu
Duration : 1 year (2021-2022)
Partners : VoiceMed
Financing : LNS, Covid-X (European fund)
Goal : To provide a genomic map of circulating SARS-CoV-2 variants in Luxembourg in order to identify new Variants of Concern, to understand their modes of transmission, to develop RT-qPCR tests discerning these variants and to test antivirals directly on the strains of interest.
Service : Department of Microbiology
LNS contact : tamir.abdelrahman@lns.etat.lu
Duration : 2 years (2021-2023)
Financing : LNS, Ministry of Health
Goal : Project to detect and quantify SARS-CoV-2 in Luxembourg wastewater by RT-qPCR in order to follow the dynamics of Covid in the human population. Use of different sequencing approaches to identify circulating variants.
Service : Department of Microbiology
LNS contact : guillaume.fournier@lns.etat.lu
Duration : 8 months (2020-2021)
Partners : Luxembourg Institute of Science and Technologies – LIST, Luxembourg Institute of Health – LIH, Luxembourg Center for Systems Biomedicine – LCSB
Financing : Fonds National de la Recherche (FNR)
Goal : Validation of standard antigen SARS-CoV-2 tests, and comparison to the “gold standard” PCR, on deceased persons for use as a rapid pre-autopsy screening method.
Service : Forensic medical service
Duration : ongoing (since May 2021)
Financing : LNS
Goal : The LNS, as the national reference laboratory for respiratory viral infections, is evaluating the reliability of different diagnostic methods for COVID in order to assist the Directorate of Health in improving the national diagnostic and surveillance strategy for COVID-19.
Service : Microbiology department
LNS contact : tamir.abdelrahman@lns.etat.lu
Duration : 12 months (2021)
Partners : Ministry of Health, Centre Hosptalier Emile Mayrisch – CHEM
Financing : Direction de la Santé, LNS
Goal : Supporting Senegal and Guinea Bissau in identifying HIV resistance, reinforcing early HBV and HPV testing in Casamance region (Senegal) and Bissau (Guinea-Bissau).
Service : Department of Microbiology
LNS contact : trung.nguyen@lns.etat.lu
Duration : 4 years (2019-2023)
Partners : ONG SAN/ACCESS ; LIH; CHL; ENDA-Santé ; Assane Esck University of Ziguinchor ; Johns Hopkins University; Local Hospitals and laboratories.
Financing : Fondation Recherche sur le Sida
Goal : Creation of a bank of multi-resistant bacterial strains. Collection, identification and characterization by antibiotic susceptibility testing of bacterial strains resistant to carbapenems or colistin from all over Europe (36 countries).
Service : MYCOBAC-ARH Service
LNS contact : alexandre.mzabi@lns.etat.lu
Duration : 3 years (2019-2021)
Partners : IBBL
Financing : European Centre for Disease Prevention and Control – ECDC
Link to the project : https://lns.lu/libbl-et-le-lns-creent-mirabank-une-banque-de-souches-bacteriennes-multiresistantes-au-luxembourg/
Goal: Stability of medicines in an ambulance under real working conditions
Service: Analytical toxicology, pharmaceutical chemistry
Duration: 1 year
Partners: CGDIS
Financing: CGDIS
Goal: Better understanding of the quantity of drugs consumed in Luxembourg based on their screening in wastewater
Service: Analytical toxicology, pharmaceutical chemistry
Duration: 1.5 years
Partners: Ministry of Health, Luxembourg Institute of Science and Technologies – LIST
Financing: Fund for the fight against certain forms of crime
Goal: Evaluate the quality of medicines seized by customs which do not have a marketing authorization in Luxembourg
Service: Analytical toxicology, pharmaceutical chemistry
Duration: 2 years
Partners: Customs
Goal: Better knowledge of the quality of drugs which are consumed in drug consumption rooms (Abrigado and JDH) and during certain festivities.
Service: Analytical toxicology, pharmaceutical chemistry
Duration: 2 years
Partners: Ministry of Health, Justice, Abrigado, 4motion
Financing: Fund for the fight against certain forms of crime
Goal: To investigate on the phenomenon of recurring genotypes of Campylobacter jejuni infecting human over the last decade in Luxembourg. To explain the persistence over time of these genotypes regarding their survival strategy. To verify whether wild birds could be involved in the geographic spread of these clones in Europe.
Service : Epidemiology and Microbial Genomics
Duration : 2018-2022
Partners : Luxembourg Institute of Science and Technologies – LIST, University of Luxembourg- UL, Institut National de la Recherche Agronomique – INRAE, Norwegian University of Life Sciences – NMBU.
Financing : Fonds National de la Recherche (FNR)
Links to the project :
https://www.fnr.lu/projects/one-health-genomics-of-campylobacter-jejuni-in-luxembourg/
https://www.frontiersin.org/articles/10.3389/fcimb.2020.608020/full
Goal: Drug research in samples submitted by drug users in order to raise awareness and to have a better overview of the drugs consumed in Luxembourg.
Unit: Technical platform for analytical toxicology and pharmaceutical chemistry
Duration: 2017 – 2018
Partners : 4motion, Police Grand-Ducale, Justice, Ministère de la Santé
Funding: Œuvre Nationale de Secours Grande-Duchesse Charlotte
Link to the projet : http://pipapo.lu/
Goal: Research and dosage of certain drugs (amphetamine, methamphetamine, cannabis metabolite, cocaine, ecstasy, heroin metabolite) in various water treatment plants in the Grand Duchy of Luxembourg.
Unit: Technical platform for analytical toxicology and pharmaceutical chemistry
Duration : 2017 – 2018
Partners : Luxembourg Institute of Science and Technologies – LIST
Funding: Fonds de lutte contre certaines formes de criminalité
Goal: Assay of different cannabinoids (THC, THCa, CBD, CBDa, CBG, CBGa, CBN) and terpenes (a-pinene, b-myrcene, linalool, b-caryphyllene, humulene, guaiol, limonene) in hemp at different stages of maturation of plants.
Unit: Technical platform for analytical toxicology and pharmaceutical chemistry
Duration: September 2016 – September 2018
Partners : Cannad’Our
Funding: Cannad’Our
Goal: Collection of samples during 3 campaigns and dosage paracetamol, desloratidine, ivermectin, arbamazepine
Unit: Technical platform for analytical toxicology and pharmaceutical chemistry
Duration: 2017 – 2018
Partners: Association pour l’optimisation de la qualité des soins – ASOQS
Funding: ASOQS
Goal: Measuring the impact of the HPV vaccination program on cervical cancer.
Unit: Epidemiology and microbial genomics
Duration : 2015 – 2018
Partners : Planning Familial, Inspection Générale de la Sécurité Sociale, Direction de la Santé, Institut de Santé Publique WIV-ISP (Bruxelles), Université de Gand
Funding: Fonds National de la Recherche (FNR)
Link to : http://www.dmidjournal.com/article/S0732-8893(16)30089-X/abstract
Goals: To study the contamination of surface waters by Campylobacter in Luxembourg. / to develop a sufficiently discriminating molecular typing scheme for the real-time detection of micro-epidemics and identification of potential sources of infection. / To type clinical, food, veterinary and environmental strains isolated over 2 years (2011-2012) and compare their genotypes. / To assess and quantify the various routes of transmission of campylobacteriosis in Luxembourg.
Unit: Epidemiology and microbial genomics
Duration : 2010 – 2013
Partners : Luxembourg Institute of Science and Technologies – LIST, Luxembourg Institute of Health – LIH
Funding: Fonds National de la Recherche (FNR)
Links to :
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-014-0205-7 /
https://www.nature.com/articles/srep20939 /
http://www.sciencedirect.com/science/article/pii/S0043135416303955